Research Article

The Skin Barrier in Patients with Lichen Simplex Chronicus in the conditions of A COVID-19 Pandemic

Filka Georgieva
Medical University of Varna, Bulgaria
* Corresponding author
DOI icon 10.24018/ejmed.2022.4.3.1353

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Submitted 2022-04-30
Published 2022-06-17

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Table of Contents

Article Main Content

Background: The primary role of the skin is to protect the body from environmental factors. The intact skin is a barrier to the uncontrolled water loss, proteins and plasma components from the organism. Frequent hand and body wash has a negative impact on skin ecosystem by removing lipids which naturally preserve and protect it.

Objective: The purpose of this study is to evaluate changes in barrier functions of skin in the condition of repeated body and hand wash in Lichen Simplex Chronicus (LSH) patients.

Materials and Methods: Transepidermal Water Loss (TEWL) and Hydratation (H) of epidermis in healthy and damaged skin were measured in 36 non-hospitalized LSH patients. The results were compared with those from a similar study but in patients before the COVID pandemic recommended hygiene regimen.

Results: The results reported in the present study showed significantly more pronounced skin barrier disorders compared to those announced in LSH patients before the COVID pandemic.

Conclusion: All the reported and analyzed results indicate that disorders of skin barrier are connected with severity and duration of LSH. The frequent washing regime act as an additional reduction of the barrier function of the skin and thus worsens the parameters of the disease.

Keywords: Frequent body wash, Hydratation, Lichen Simplex Chronicus, Skin Barrier Evaluation, TEWL

References

  1. Grice EA, Segre JA. The skin microbiome. Nature Reviews. Microbiology. 2011; 9(4): 244-53.
     Google Scholar
  2. Segre JA. Epidermal barrier formation and recovery in skin disorders. J Clin Invest. 2006; 116(5): 1150-8.
     Google Scholar
  3. Lefèvre-Utile A, Braun C, Haftek M, Aubin F. Five Functional Aspects of the Epidermal Barrier. Int J Mol Sci. 2021; 22: 11676.
     Google Scholar
  4. Navare B, Thakur S, Nakle S. A review on surfactants: Role in skin, irritation, SC damage, and effect of mild cleansing overdamaged skin. Int. J Adv Res Ideas Innov. Technol. 2019; 5: 1077–1081.
     Google Scholar
  5. Del Rosso JQ, Levin J. The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. J Clin Aesthetic Dermatol. 2011; 4: 22–42.
     Google Scholar
  6. Serup J, Gregor BE, Grove GL. Handbook of non-invasive methods and the skin. 2nd ed. CRC press, 2006.
     Google Scholar
  7. Georgieva F, Bakardzhiev I The Skin Barrier in Patients with Lichen Simplex Chronicus. Clin Res Dermatol Open Access. 2016; 3(3): 1-4.
     Google Scholar
  8. Daye M, Cihan FG, Durduran Y. Evaluation of skin problems and dermatology life quality index in health care workers who use personal protection measures during COVID-19 pandemic. Dermatol Ther. 2020; 33(6): e14346.
     Google Scholar
  9. Babić Ž, Šakić F, Franić Z, Macan J. Skin barrier function in nursing apprentices during the coronavirus disease 2019 (COVID-19) pandemic. Contact Dermatitis. 2022.
     Google Scholar
  10. James WD, Berger TG, Elston DM, Odom RB. Andrews’ Diseases of the Skin. Saunders Elsevier. 10th ed. 2006.
     Google Scholar
  11. Williams ML. Lipids in normal and pathological desquamation. In: Elias PM, ed. Skin Lipids, NY: Academic Press. 2011; 24: 211-262.
     Google Scholar
  12. Jansen van Rensburg S, Franken A, Du Plessis JL. Measurement of transepidermal water loss, stratum corneum hydration and skin surface pH in occupational settings: A review. Skin Res Technol. 2019; 25(5): 595-605.
     Google Scholar
  13. Kiely LF, Moloney E, O'Sullivan G, Eustace JA, Gallagher J, Bourke JF. Irritant contact dermatitis in healthcare workers as a result of the COVID-19 pandemic: a cross-sectional study. Clin Exp Dermatol. 2021; 46(1): 142-144.
     Google Scholar
  14. Mirali S, Fleming P, Lynde CW. Moisturizers and Cleansers in the Management of Skin Conditions Caused by Personal Protective Equipment and Frequent Handwashing. Skin Therapy Lett. 2021; 26(4): 9-13.
     Google Scholar