San Diego State University, USA
* Corresponding author

Article Main Content

Biology does not completely explain dementia. We can neither predict nor confirm a diagnosis of dementia based purely on its biology. Recent studies looking at prevention using social interventions hold better promise for ameliorating the disease. Yet, we do not have a major theory to explain these outcomes without resorting to biology. By understanding that there are mediating and moderating psychological factors promoting dementia, we take a broader view of the disease than a simple binary approach. Psychology plays a vital role in this clinical disease, in how cognition affects dementia. The presumption is that all of cognition: perception, orientation, novelty, attention, the application of knowledge (praxis), calculation, language, abstract thinking, and memory can affect and bring about dementia. It is not dementia that causes cognitive decline but cognitive decline that causes dementia. The psychopathology of dementia can initiate dementia, moderate it by enhancing or retarding the progression of the disease or mediate the disease by acting as a confirmatory process. The tipping point expressed by apathy and depression heralds a change in cognition. The psychopathology of dementia is important in understanding the etiology of dementia as it holds the most promising avenue for curing some dementias.

References

  1. C. R. Jack Jr, M. S. Albert, D. S. Knopman, G. M. McKhann, R. A. Sperling, M. C. Carrillo and C. H. Phelps, “Introduction to the recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease,” Alzheimer's & Dementia 7(3): 257-262, 2011.
     Google Scholar
  2. C. R. Jack Jr, D. A. Bennett, K. Blennow, M. C. Carrillo, B. Dunn, S. B. Haeberlein and N. Silverberg, “NIA‐AA research framework: toward a biological definition of Alzheimer's disease,” Alzheimer's & Dementia 14(4): 535-562, 2018.
     Google Scholar
  3. C. Hock, U. Konietzko, J. R. Streffer, J. Tracy, A. Signorell, B. Müller-Tillmanns and R. M. Nitsch, “Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease,” Neuron 38(4): 547-554, 2003.
     Google Scholar
  4. K. Iqbal, F. Liu and C. X. Gong, “Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles,” Biochemical Pharmacology 88(4), 631-639, 2014.
     Google Scholar
  5. C. Holmes, D. Boche, D. Wilkinson, G. Yadegarfar, V. Hopkins, A. Bayer and J. A. Nicoll, “Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial,” The Lancet 372(9634): 216-223, 2008.
     Google Scholar
  6. S. Gilman, M. Koller, R. S. Black, L. Jenkins, S. G. Griffith, N. C. Fox and J. M. Orgogozo, “Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial,” Neurology 64(9): 1553-1562, 2005.
     Google Scholar
  7. A. J. Bayer, R. Bullock, R. W. Jones, D. Wilkinson, K. R. Paterson, L. Jenkins and S. Donoghue, “Evaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD,” Neurology 64(1), 94-101, 2005.
     Google Scholar
  8. B. N. Cuthbert, “The role of RDoC in future classification of mental disorders,” Dialogues in Clinical Neuroscience 22(1): 81, 2020,
     Google Scholar
  9. H. A. Crystal, D. Dickson, P. Davies, D. Masur, E. Grober and R. B. Lipton, “The relative frequency of dementia of unknown etiology increases with age and is nearly 50% in nonagenarians,” Archives of Neurology 57(5): 713-719, 2000.
     Google Scholar
  10. T. Polvikoski, R. Sulkava, L. Myllykangas, I. L. Notkola, L. Niinistö, A. Verkkoniemi and M. Haltia, “Prevalence of Alzheimer’s disease in very elderly people: a prospective neuropathological study,” Neurology 56(12): 1690-1696, 2001.
     Google Scholar
  11. R. Katzman, R. Terry, R. DeTeresa, T. Brown, P. Davies, P. Fuld and A. Peck, “Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques,” Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society 23(2): 138-144, 1988.
     Google Scholar
  12. D. G. Davis, F. A. Schmitt, D. R. Wekstein and W. R. Markesbery, “Alzheimer neuropathologic alterations in aged cognitively normal subjects,” Journal of Neuropathology and Experimental Neurology 58(4): 376-388, 1999.
     Google Scholar
  13. J. L. Price and J. C. Morris. “Tangles and Plaques in Nondemented Aging and "preclinical.” Alzheimer’s Disease. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society 45(3): 358–68, 1999.
     Google Scholar
  14. D. Knopman, “Pharmacotherapy for Alzheimer’s Disease: 2002.” Clinical Neuropharmacology 26(2), 93-101, 2002.
     Google Scholar
  15. D. A. Snowdon, L. H. Greiner, J. A. Mortimer, K. P. Riley, P. A. Greiner and W. R. Markesbery, “Brain infarction and the clinical expression of Alzheimer disease: the Nun Study,” Jama 277(10), 813-817, 1997.
     Google Scholar
  16. D. W. Dickson, “Neuropathological Diagnosis of Alzheimer’s Disease: A Perspective from Longitudinal Clinicopathological Studies.” Neurobiology of Aging 18(4): 21-26, 1997.
     Google Scholar
  17. B. E. Tomlinson, G. Blessed and M. Roth, “Observations on the brains of demented old people,” Journal of the Neurological Sciences 11(3): 205-242, 1970.
     Google Scholar
  18. H. Braak, D. R. Thal, E. Ghebremedhin and K. Del Tredici, “Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years,” Journal of Neuropathology & Experimental Neurology 70(11): 960-969, 2011.
     Google Scholar
  19. G. M. Savva, S. B. Wharton, P. G. Ince, G. Forster, F. E. Matthews and C. Brayne, “Age, neuropathology, and dementia,” New England Journal of Medicine 360(22): 2302-2309, 2009.
     Google Scholar
  20. M. D. Garrett, Politics of Anguish: How Alzheimer's disease became the malady of the 21st century Createspace, 2015.
     Google Scholar
  21. D. E. Bredesen and V. John “Next Generation Therapeutics for Alzheimer’s Disease,” EMBO Mol Med 5(975), 2013.
     Google Scholar
  22. D. E. Bredesen, Reversal of Cognitive Decline: A Novel Therapeutic Program, Aging, Albany NY, 6(9), 2014.
     Google Scholar
  23. M. Kivipelto, A. Solomon, S. Ahtiluoto, T. Ngandu, J. Lehtisalo, R. Antikainen and H. Soininen, “The Finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER): study design and progress,” Alzheimer's & Dementia 9(6): 657-665, 2013.
     Google Scholar
  24. M. Kivipelto, F. Mangialasche, H. M. Snyder, R. Allegri, S. Andrieu, H. Arai and M. C. Carrillo, “World‐Wide FINGERS Network: a global approach to risk reduction and prevention of dementia,” Alzheimer's & Dementia 16(7): 1078-1094, 2020.
     Google Scholar
  25. M. Garrett, “Multiple Causes of Dementia as Engineered Senescence.” European Journal of Medical and Health Science 2(2), 2020.
     Google Scholar
  26. I. G. McKeith, D. Galasko, K. Kosaka, E. K. Perry, D. W. Dickson, L. A. Hansen and R. H. Perry, “Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop,” Neurology 47(5): 1113-1124, 1996.
     Google Scholar
  27. C. F. Vahl, “Lewy Body and Parkinsonian Dementia: Common, but Often Misdiagnosed Conditions: Hydrocephalus Should Not Be Forgotten.Deutsches,” Arzteblatt International 108(8): 131, 2011.
     Google Scholar
  28. J. S. Schiller, J. W. Lucas and J. A. Peregoy, “Summary Health Statistics for U.S. Adults:National Health Interview Survey, 2011,” National Center for Health Statistics Vital Health Stat 10(256), 2012.
     Google Scholar
  29. T. Wetterling, R. D. Kanitz and K. J. Borgis, “Comparison of different diagnostic criteria for vascular dementia (ADDTC, DSM-IV, ICD-10, NINDS-AIREN),” Stroke 27(1): 30-36, 1996.
     Google Scholar
  30. G. H. Brody, T. Yu, E. Chen, S. R. Beach and G. E. Miller, (2016). “Family‐centered prevention ameliorates the longitudinal association between risky family processes and epigenetic aging,” Journal of Child Psychology and Psychiatry 57(5): 566-574, 2016.
     Google Scholar
  31. I. Požgain, Z. Požgain and D. Degmečić, “Placebo and nocebo effect: a mini-review.” Psychiatria Danubina 26(2): 0-107, 2014.
     Google Scholar
  32. I. E. Dror, I. C. Schmitz-Williams and W. Smith, “Older adults use mental representations that reduce cognitive load: mental rotation utilizes holistic representations and processing,” Experimental Aging Research 31(4): 409-420, 2005.
     Google Scholar
  33. F. Blanchard-Fields, A. Mienaltowski and R. B. Seay, “Age differences in everyday problem-solving effectiveness: Older adults select more effective strategies for interpersonal problems,” The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 62(1): 61-64, 2007.
     Google Scholar
  34. H. Shimada, H. Makizako, H. Park, T. Doi and S. Lee, “Validity of the National Center for Geriatrics and Gerontology‐Functional Assessment Tool and Mini‐Mental State Examination for detecting the incidence of dementia in older Japanese adults,” Geriatrics & Gerontology International 17(12): 2383-2388, 2017.
     Google Scholar
  35. M. Maltz and D. Shinar. “Eye Movements of Younger and Older Drivers.” Human Factors 41(1): 15-25, 1999.
     Google Scholar
  36. D. J. Simons and C. F. Chabris. “Gorillas in Our Midst: Sustained Inattentional Blindness for Dynamic Events.” Perception 28(9): 1059-74, 1999.
     Google Scholar
  37. A. F. Williams and O. Carsten. “Driver Age and Crash Involvement.” American Journal of Public Health 79(3), 326–27, 1989.
     Google Scholar
  38. S. M. Retchin and J. Anapolle, “An Overview of the Older Driver.” Clinics in Geriatric Medicine 9(2): 279–96, 1993.
     Google Scholar
  39. J. M. Lyman, G. McGwin Jr and R.V. Sims, “Factors Related to Driving Difficulty and Habits in Older Drivers.” Accident Analysis & Prevention 33(3):413-21, 2001.
     Google Scholar
  40. T. D. Willstrand, T. Broberg and H. Selander, “Driving characteristics of older drivers and their relationship to the useful field of view test,” Gerontology 63(2): 180-188, 2017.
     Google Scholar
  41. T. Fritsch, K. A. Smyth, S. M. Debanne, G. J. Petot and R. P. Friedland, “Participation in novelty-seeking leisure activities and Alzheimer’s disease,” Journal of Geriatric Psychiatry and Neurology 18(3): 134-141, 2005.
     Google Scholar
  42. B. D. Glass, W. T. Maddox and B. C. Love, “Real-time strategy game training: emergence of a cognitive flexibility trait,” Plos One 8(8): e70350, 2013.
     Google Scholar
  43. L. J. Tranter and W. Koutstaal, “Age and Flexible Thinking: An Experimental Demonstration of the Beneficial Effects of Increased Cognitively Stimulating Activity on Fluid Intelligence in Healthy Older Adults.” Aging, Neuropsychology, and Cognition 15(2): 184-207, 2008.
     Google Scholar
  44. E. A. Stine-Morrow, J. M. Parisi, D. G. Morrow and D. C. Park, “The effects of an engaged lifestyle on cognitive vitality: a field experiment,” Psychology and Aging 23(4): 778, 2008.
     Google Scholar
  45. M. C. Carlson, J. S. Saczynski, G. W. Rebok, T. Seeman, T. A. Glass, S. McGill and L. P. Fried, “Exploring the effects of an “everyday” activity program on executive function and memory in older adults: Experience Corps®,” The Gerontologist 48(6): 793-801, 2008.
     Google Scholar
  46. J. A. Bugos, W. M. Perlstein, C. S. McCrae, T. S. Brophy and P. H. Bedenbaugh, “Individualized piano instruction enhances executive functioning and working memory in older adults,” Aging and Mental Health 11(4): 464-471, 2007.
     Google Scholar
  47. J. A. Mortimer, D. Ding, A. R. Borenstein, C. DeCarli, Q. Guo, Y. Wu and S. Chu, “Changes in brain volume and cognition in a randomized trial of exercise and social interaction in a community-based sample of non-demented Chinese elders,” Journal of Alzheimer's Disease 30(4), 757-766, 2012.
     Google Scholar
  48. P. Fissler, O. Kuester, W. Schlee and I. T. Kolassa, “Novelty interventions to enhance broad cognitive abilities and prevent dementia: synergistic approaches for the facilitation of positive plastic change,” Progress in Brain Research 207, 403-434, 2013.
     Google Scholar
  49. E. A. Maguire, K. Woollett and H. J. Spiers, “London taxi drivers and bus drivers: a structural MRI and neuropsychological analysis,” Hippocampus 16(12): 1091-1101, 2006.
     Google Scholar
  50. M. Cappelletti, D. Didino, I. Stoianov and M. Zorzi, “Number skills are maintained in healthy ageing,” Cognitive Psychology 69, 25-45, 2014.
     Google Scholar
  51. G. Deloche, D. Mannequin, S. Carlomagno, A. Agniel, M. Dordain, F. Pasquier and X. Seron, “Calculation and number processing in mild Alzheimer's disease,” Journal of Clinical and Experimental Neuropsychology 17(4): 634-639, 1995.
     Google Scholar
  52. A. M. Kennedy, S. K. Newman, R. S. J. Frackowiak, V. J. Cunningham, P. Roques, J. Stevens and M. N. Rossor, “Chromosome 14 linked familial Alzheimer's disease: A clinico-pathological study of a single pedigree,” Brain 118(1): 185-205, 1995.
     Google Scholar
  53. R. McGlinchey-Berroth, W. P. Milberg and N. Charness, “Learning of a complex arithmetic skill in dementia: Further evidence for a dissociation between compilation and production,” Cortex 25(4): 697-705, 1989.
     Google Scholar
  54. H. Diesfeldt, “Progressive Decline of Semantic Memory with Preservation of Number Processing and Calculation,” Behavioural Neurology 6, 239-42, 1993.
     Google Scholar
  55. L. Girelli and M. Delazer, “Numerical abilities in dementia.” Aphasiology 15(7), 681–94, 2001.
     Google Scholar
  56. P. Wallich, “Senile Words.” Scientific American 274(6), 26-27, 1996.
     Google Scholar
  57. S. Daigneault, C. M. Braun and H. A. Whitaker, “Early effects of normal aging on perseverative and non‐perseverative prefrontal measures,” Developmental Neuropsychology 8(1): 99-114, 1992.
     Google Scholar
  58. P. K. Kuhl, “Early Language Acquisition: Cracking the Speech Code.” Nature Reviews Neuroscience 5(11): 831–43, 2004.
     Google Scholar
  59. O. Pascalis, L. S. Scott, D. J. Kelly, R. W. Shannon, E. Nicholson, M. Coleman and C. A. Nelson, “Plasticity of face processing in infancy,” Proceedings of the National Academy of Sciences 102(14): 5297-5300, 2005.
     Google Scholar
  60. T. P. German and M. A. Defeyter. “Immunity to Functional Fixedness in Young Children,” Psychonomic Bulletin and Review 7(4): 707-12, 2000.
     Google Scholar
  61. C. G. Lucas, S. Bridgers, T. L. Griffiths and A. Gopnik, “When children are better (or at least more open-minded) learners than adults: Developmental differences in learning the forms of causal relationships,” Cognition 131(2): 284-299, 2014.
     Google Scholar
  62. P. H. Miller, Piaget’s Theory: Past, Present, and Future 2011.
     Google Scholar
  63. T. Metitieri, O. Zanetti, C. Geroldi, G. B. Frisoni, D. De Leo, M. D. Buono and M. Trabucchi, “Reality orientation therapy to delay outcomes of progression in patients with dementia. A retrospective study,” Clinical Rehabilitation 15(5): 471-478, 2001.
     Google Scholar
  64. C. Jonker, M. I. Geerlings and B. Schmand, “Are memory complaints predictive for dementia? A review of clinical and population‐based studies,” International Journal of Geriatric Psychiatry 15(11): 983-991, 2000.
     Google Scholar
  65. S. Hamann, “Cognitive and neural mechanisms of emotional memory.” Trends in Cognitive Sciences 5, 394–400, 2001.
     Google Scholar
  66. E. A. Kensinger, “Remembering Emotional Experiences: The Contribution of Valence and Arousal.” Reviews in the Neurosciences 15(4), 241–52, 2004.
     Google Scholar
  67. K. S. LaBar and R. Cabeza. “Cognitive Neuroscience of Emotional Memory.” Nature Reviews Neuroscience 7, 54–64, 2006.
     Google Scholar
  68. L. J. Levine, “Reconstructing Memory for Emotions.” Journal of Experimental Psychology: General 126(2), 165–77, 1997.
     Google Scholar
  69. H. Schmolck, E. A. Buffalo and L. R. Squire, “Memory distortions develop over time: Recollections of the OJ Simpson trial verdict after 15 and 32 months,” Psychological Science 11(1): 39-45, 2000.
     Google Scholar
  70. J. M. Talarico and D. C. Rubin. “Confidence, not consistency, characterizes flashbulb memories.” Psychological Science 14(5): 455–61, 2003.
     Google Scholar
  71. K. A. Deffenbacher and E. F. Loftus, “Do jurors share a common understanding concerning eyewitness behavior?” Law and Human Behavior 6(1): 15-30, 1982.
     Google Scholar
  72. A. M. Glenberg, “What Memory Is For.” Behavioral and Brain Sciences 20(1): 1–19, 1997.
     Google Scholar
  73. H. Merckelbach, M. Dalsklev, D. van Helvoort, I. Boskovic and H. Otgaar, “Symptom self-reports are susceptible to misinformation,” Psychology of Consciousness: Theory, Research, and Practice 5(4): 384, 2018.
     Google Scholar
  74. H. Merckelbach, M. Jelicic and C. Jonker, “Planting a misdiagnosis of Alzheimer’s disease in a person’s mind.” Acta Neuropsychiatrica, 24(1), 60–62, 2012.
     Google Scholar
  75. K. H. Campbell, C. B. Stocking, G. W. Hougham, P. J. Whitehouse, D. D. Danner and G. A. Sachs, “Dementia, diagnostic disclosure, and self‐reported health status,” Journal of the American Geriatrics Society 56(2): 296-300, 2008.
     Google Scholar
  76. S. A. Wolf, M. Henry, R. Deike, A. D. Ebert and C. W. Wallesch, “Verdachtsdiagnose Alzheimer-Demenz,” Der Nervenarzt 79(4): 444-453, 2008.
     Google Scholar
  77. M. Ross, “Relation of Implicit Theories to the Construction of Personal Histories.” Psychological Review 96(2), 341, 1989.
     Google Scholar
  78. M. Conway, “On Bias in Autobiographical Recall: Retrospective Adjustments Following Disconfirmed Expectations.” The Journal of Social Psychology 130(2): 183–89, 1990.
     Google Scholar
  79. L. V. Karnatovskaia, K. L. Philbrick, A. M. Parker and D. M. Needham, “Early psychological therapy in critical illness,” Respiratory and Critical Care Medicine 37(1): 136-142, 2016.
     Google Scholar
  80. A. K. Szilágyi, C. Diószeghy, L. Benczúr and K. Varga, “Effectiveness of psychological support based on positive suggestion with the ventilated patient,” European Journal of Mental Health 2(2), 149, 2007.
     Google Scholar
  81. A. K. Szilágyi, C.Diószeghy, G. Fritúz, J. Gál and K. Varga, “Shortening the length of stay and mechanical ventilation time by using positive suggestions via MP3 players for ventilated patients,” Interventional Medicine and Applied Science 6(1): 3-15, 2014.
     Google Scholar
  82. U. NIlsson, N. Rawal, B. Enqvist and M. Unosson, “Analgesia following music and therapeutic suggestions in the PACU in ambulatory surgery; a randomized controlled trial,” Acta Anaesthesiologica Scandinavica 47(3): 278-283, 2003.
     Google Scholar
  83. A. H. Lebovits, R. Twersky and B. McEwan, “Intraoperative therapeutic suggestions in day-case surgery: are there benefits for postoperative outcome?” British Journal of Anaesthesia 82(6): 861-866, 1999.
     Google Scholar
  84. T. McLintock, H. Aitken, C. F. Downie and G. N. Kenny, “Postoperative analgesic requirements in patients exposed to positive intraoperative suggestions,” British Medical Journal 301(6755): 788-790, 1990.
     Google Scholar
  85. J. Schlanger, G. Fritúz and K. Varga, “Therapeutic suggestion helps to cut back on drug intake for mechanically ventilated patients in intensive care unit,” Interventional Medicine and Applied Science 5(4): 145-152, 2013.
     Google Scholar
  86. K. Thorsen, M. C. N. Dourado and A. Johannessen, “Developing dementia: the existential experience of the quality of life with young-onset dementia–a longitudinal case study,” Dementia 19(3): 878-893, 2020.
     Google Scholar
  87. C. R. Weinert, C. R. Gross, J. R. Kangas, C. L. Bury and W. A. Marinelli, “Health-related quality of life after acute lung injury,” American Journal of Respiratory and Critical Care Medicine 156(4): 1120-1128, 1997.
     Google Scholar
  88. A. Koppara, M. Wagner, C. Lange, A. Ernst, B. Wiese, H. H. König and F. Jessen, “Cognitive performance before and after the onset of subjective cognitive decline in old age,” Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 1(2): 194-205, 2015.
     Google Scholar
  89. D. D. Brigham and P. O. Toal, “The Use of Imagery in a Multimodal Psychoneuroimmunology Program for Cancer and Other Chronic Diseases.” Mental Imagery, 193–98, 1990.
     Google Scholar
  90. T. M. Hess, C. Auman, S. J. Colcombe and T. A. Rahhal, “The impact of stereotype threat on age differences in memory performance,” The Journals of Gerontology Series B: Psychological Sciences and Social Sciences 58(1): 3-11, 2003.
     Google Scholar
  91. M. Fresson, B. Dardenne, M. Geurten and T. Meulemans, “The effect of stereotype threat on older people’s clinical cognitive outcomes: Investigating the moderating role of dementia worry,” The Clinical Neuropsychologis, 31(8): 1306-1328, 2017.
     Google Scholar
  92. C. Haslam, T. A. Morton, S. A. Haslam, L. Varnes, R. Graham and L. Gamaz, “When the age is in, the wit is out: Age-related self-categorization and deficit expectations reduce performance on clinical tests used in dementia assessment,” Psychology and Aging 27(3): 778, 2012.
     Google Scholar
  93. D. Buettner, The Blue Zones: 9 Lessons for Living Longer from the People Who’ve Lived the Longest, National Geographic Books, 2012.
     Google Scholar
  94. V. Bellou, L. Belbasis, I. Tzoulaki, L. T. Middleton, J. P. Ioannidis and E. Evangelou, “Systematic evaluation of the associations between environmental risk factors and dementia: an umbrella review of systematic reviews and meta-analyses,” Alzheimer's & Dementia 13(4): 406-418, 2017.
     Google Scholar
  95. L. Fratiglioni and H. X. Wang, “Brain Reserve Hypothesis in Dementia.” Journal of Alzheimer’s Disease 12(1): 11–22, 2007.
     Google Scholar
  96. M. J. Valenzuela and P. Sachdev. “Brain reserve and dementia: a systematic review.” Psychological Medicine 36(4): 441,2006.
     Google Scholar
  97. S. Forstmeier, A. Maercker, W. Maier, H. Van Den Bussche, S. Riedel-Heller, H. Kaduszkiewicz and M. Wagner, “Motivational reserve: motivation-related occupational abilities and risk of mild cognitive impairment and Alzheimer disease,” Psychology and Aging 27(2): 353, 2012.
     Google Scholar
  98. S. Forstmeier and A. Maercker, “Motivational Reserve: Lifetime Motivational Abilities Contribute to Cognitive and Emotional Health in Old Age.” Psychology and Aging 23(4),886, 2008.
     Google Scholar
  99. P. A. Boyle, A. S. Buchman, L. L. Barnes and D. A. Bennett, “Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in community-dwelling older persons,” Archives of General Psychiatry 67(3): 304-310, 2010.
     Google Scholar
  100. M. A. Bock, A. Bahorik, W. D. Brenowitz and K. Yaffe, “Apathy and risk of probable incident dementia among community-dwelling older adults,” Neurology 95(24): e3280-e3287, 2020.
     Google Scholar
  101. R. L. Ownby, E. Crocco, A. Acevedo, V. John and D. Loewenstein, “Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis,” Archives of General Psychiatry 63(5): 530-538, 2006.
     Google Scholar
  102. A. Mowla, H. Ashkani, A. Ghanizadeh, G. R. Dehbozorgi, B. Sabayan and A. H. Chohedri, “Do memory complaints represent impaired memory performance in patients with major depressive disorder?” Depression and Anxiety 25(10): E92-E96, 2008.
     Google Scholar
  103. D. P. Devanand, M. Sano, M. X. Tang, S. Taylor, B. J. Gurland, D. Wilder and R. Mayeux, “Depressed mood and the incidence of Alzheimer's disease in the elderly living in the community,” Archives of General Psychiatry, 53(2): 175-182, 1996.
     Google Scholar
  104. R. A. Sweet, R. L. Hamilton, M. A. Butters, B. H. Mulsant, B. G. Pollock, D. A. Lewis and C. F. Reynolds, “Neuropathologic correlates of late-onset major depression,” Neuropsychopharmacology 29(12): 2242-2250, 2004.
     Google Scholar
  105. M. El Haj, P. Antoine, J. L. Nandrino and D. Kapogiannis, “Autobiographical memory decline in Alzheimer’s disease, a theoretical and clinical overview,” Ageing Research Reviews 23, 183-192, 2015.
     Google Scholar
  106. M. Amanzio, G. Geminiani, D. Leotta and S. Cappa, “Metaphor comprehension in Alzheimer’s disease: Novelty matters,” Brain and Language 107(1): 1-10, 2008.
     Google Scholar
  107. C. Stern and Z. Munn. “Cognitive Leisure Activities and Their Role in Preventing Dementia: A Systematic Review,” International Journal of Evidence‐Based Healthcare 8(1), 2–17, 2010.
     Google Scholar
  108. P. Enck, F. Benedetti and M. Schedlowski, “New insights into the placebo and nocebo responses,” Neuron 59(2): 195-206, 2008.
     Google Scholar
  109. F. Benedetti and A. Shaibani, “Nocebo effects: more investigation is needed,” Expert Opinion on Drug Safety 17(6): 541-543, 2018.
     Google Scholar
  110. E. Loftus, “The Fiction of Memory,” 2020.
     Google Scholar
  111. A. M. Clarfield, “The Reversible Dementias: Do They Reverse?” Ann Intern Med 109(6): 476–86, 1988.
     Google Scholar
  112. M. D. Weytingh, P. M. M. Bossuyt and H. Van Crevel, “Reversible dementia: more than 10% or less than 1%?” Journal of Neurology 242(7): 466-471, 1995.
     Google Scholar
  113. M. A. Clarfield, “The Decreasing Prevalence of Reversible Dementias: An Updated Meta-Analysis.” Arch Intern Med 163(18), 2219–29, 2003.
     Google Scholar
  114. A. Hejl, P. Høgh and G. Waldemar, “Potentially reversible conditions in 1000 consecutive memory clinic patients,” Journal of Neurology, Neurosurgery & Psychiatry 73(4): 390-394, 2002.
     Google Scholar
  115. S. L. Webb, D. P. Birney, V. Loh, S. Walker, A. Lampit and A.Bahar-Fuchs, “Cognition-oriented treatments for older adults: A systematic review of the influence of depression and self-efficacy individual differences factors,” Neuropsychological Rehabilitation 1-37, 2001.
     Google Scholar
  116. M. S. Hagger, C. Wood, C. Stiff and N. L. Chatzisarantis, “Ego depletion and the strength model of self-control: a meta-analysis,” Psychological Bulletin 136(4): 495, 2010.
     Google Scholar
  117. A. M. F. J. N. Johannes and O. Ritter, “Psychological consequences of longevity,” Human Development 52, 1-37, 2009.
     Google Scholar